Table 2.
Treatment of 10 anorexia nervosa patients with extreme undernutrition a.
| Time | Day 0 | 15 days | 30 days | 60 days | 90 days |
|---|---|---|---|---|---|
| Enteral feeding regimen (kcal/day) | 450.0 | 837.5 | 1100.0 | 1000.0 | 800.0 |
| Amount of enteral fluid diet (mL/day) | 300.0 | 650.0 | 600.0 | 500.0 | 400.0 |
| Caloric density (kcal/mL) | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 |
| Protein (enteral feeding) (g/kg body weight) | 0.7 | 1.3 | 1.5 | 1.2 | 0.9 |
| Protein (oral diet) (g/kg body weight) | 1.3 | 1.5 | 1.7 | 1.8 | 1.8 |
| Protein (total)(g/kg body weight) | 2 | 2.8 | 3.0 | 2.9 | 2.6 |
| Fiber (enteral feeding) (g) | 5.0 | 11.0 | 12.5 | 12.5 | 10.0 |
| Δ Body weight b (kg) | 4.35 | 7.3 | 11.95 | 16.7 | |
| Phosphatei.v. c/oral (mg/day) | 500.0 | 500.0 | 375.0 | 250.0 | 250 (1) e |
| Glucose d i.v. infusion (kcal/day) | 200.0 | 400.0 (9) e | 400.0 (4) e | 200.0 (1) e | 200 (1) e |
| Oral diet (kcal/day) | 408 | 1204 | 1412 | 1819 | 2135 |
| Enteral feeding regimen + Glucose (kcal/day) | 800.0 | 1200.0 | 1200.0 | 1000.0 | 800.0 |
| Oral diet + enteral feeding regimen + Glucose (kcal/day) | 1199 | 2508 | 2784 | 2935 | 2871 |
a Values are medians; b Δ Body weight = increase of body weight starting from time = 0; c i.v. = intravenous; d Glucose infused by intravenous fluid (10%) during 24 h; e ( ) number of subjects; if the number is not indicated, it is understood as being 10 patients; As primary outcome we obtained a significant modification in body weight from 27.9 ± 3.3 to 43.0 ± 5.7 kg and of BMI from 11.2 ± 0.72 kg/m2 to 17.3 ± 1.6 kg/m2 (p < 0.0001).