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Midlogarithmic phase transcriptomic analysis of M1 isolates in vitro. Expression of the streptolysin O (slo)- and NAD glycohydrolase (nga)-encoding genes in M1 isolates containing intact covRS loci. Dotted line separates strains containing historic slo and nga genes (left) from those containing the contemporary allele (right) acquired from a serotype M12 donor strain. Data are presented as normalized fluorescence units; larger fluorescence values correspond with increased expression.
