Table 1.
Streptococcus pyogenes isolates and isogenic mutant strains used in this study
| Isolate | Infection | emm type | REA type | PFGE type | covRS allele | SpeB phenotype | Ref. |
|---|---|---|---|---|---|---|---|
| 89158 | I | 1.46 | b | A | WT | + | 9 |
| L485 | U | 1.0 | f | B | WT | + | 9 |
| SF370 | U | 1.6 | ND | C | WT | + | 19 |
| NS696 | U | 1.0 | ND | D | WT | + | 23 |
| AB1551 | U | 1.0 | e | D | WT | + | 9 |
| 90223 | I | 1.0 | g | E | WT | + | 9 |
| GT94052 | U | 1.0 | h | E | WT | + | 9 |
| GT94966 | I | 1.0 | d | E | WT | + | 9 |
| 5636 | I | 1.0 | c | E | WT | + | This study |
| 5448 | I | 1.0 | c | E | WT | + | 18 |
| 5448AP | AP | 1.0 | ND | ND | Mutant | − | 36 |
| 5636ΔspeA | NA | 1.0 | ND | ND | WT | + | This study |
| 5636ΔspeA-comp | NA | 1.0 | ND | ND | WT | + | This study |
AP, animal passage; I, invasive; NA, not applicable; ND, not determined; PFGE, pulsed-field gel electrophoresis; REA, restriction enzyme analysis; U, uncomplicated; WT, wild type.