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. 2012 Nov;26(11):4662–4674. doi: 10.1096/fj.12-207530

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/us/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Morphological features of mutant clones selected using morphology-based screening. Expression of VAChT-EGFP in the parental PC12-VAChT cells (A), mutant clones (B, left panels), and reverted clones (B, right panels). Fluorescence of VAChT-EGFP is diminished (P26), almost absent (P05 and P173), or aggregated in the cell body (P12). Clone P207 has multibranched neurites and intense VAChT-EGFP fluorescence at the tips of these neurites. After Cre/loxP-mediated recombination (B, right panels), these mutant clones became indistinguishable from the parental PC12 cells (PC12-VAChT). Scale bars = 100 μm.