Figure 7.

SNRK is reduced in human colon cancer tissue, and stable SNRK knockdown increases the tumorigenicity of colon cancer cells in vitro. A) Quantitative real-time PCR using primers for human SNRK was conducted on samples from matched normal and tumor human colon tissue samples using an Origene TissueScan cDNA array; n = 22–23. B) Colony formation assay in RKO cells with stable knockdown of SNRK; n = 6. NSC, stable nonsilencing control shRNA treatment. C) Soft agar colony assay in RKO cells with stable knockdown of SNRK; n = 3. *P < 0.05.