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. 2012 Sep 20;10(9):2055–2068. doi: 10.3390/md10092055

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© 2012 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Expression of epidermal growth factor receptor (EGFR) protein in sarcoma tissue (A,B). (A) Sarcoma sections from different groups were immunohistochemically stained to assay the expressions of EGFR protein. The expression of EGFR -positive cells (black arrow) was down-regulated by fucoxanthin (×200). Slides are representative of 15 animals per group; (B) Tissue homogenates from S180 sarcomas were prepared, and then the expression levels of EGFR protein in sarcoma were confirmed by western blotting. Treatment with fucoxanthin at the dose of 50 and 100 mg/kg obviously reduced EGFR expression compared with model control group. Values are the mean ± SD. * p < 0.05, ** p < 0.01 vs. control group.