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Effect of inter-CBS linker deletions Δ728-748 and Δ748-768 on channel functional properties. Mutant and WT channels were coexpressed with kinase dead or WT GCK-3. When coexpressed with kinase dead GCK-3, Δ728-748 and Δ748-768 current amplitudes (A and B), activation voltages (C) and 50% rise times (D) were similar to those of GCK-3 inhibited WT channels. Coexpression of the deletion mutants with GCK-3 had no effect on functional properties. Values are mean ± SE (n = 4–8).
