Figure 4.

R-roscovitine exerts antiinflammatory effects during gram-positive pneumonia. Gram-positive pneumonia was induced by intranasal inoculation of 5 × 10⁴ CFU serotype 3 S. pneumoniae. Ceftriaxone (20 mg/kg) in combination with 70 mg/kg R-roscovitine or vehicle (10 % DMSO) was injected intraperitoneally after 24 and 72 h. Representative lung histology of ceftriaxone and R-roscovitine + ceftriaxone treatment (A) with corresponding inflammation scores (B) is shown. Representative images of Ly-6G staining on lung slides (C) and Ly-6G⁺ lung surface percentage (D) are shown. CFUs were determined in lung homogenates (E). Data are expressed as mean ± SEM; n = 8. *P < 0.05.