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. 2012 Oct 18;3:370. doi: 10.3389/fmicb.2012.00370

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Copyright © 2012 Kampschreur, Kleerebezem, Picioreanu, Bakken, Bergaust, de Vries, Jetten and Van Loosdrecht.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Scheme of conversions and regulation of denitrification pathway in Agrobacterium tumefaciens as used in the metabolic model of the experiments. The combination of experimental data and the metabolic model led to identification of nirK and norB transcription activated by their substrates, nap transcription by oxygen limitation, apparent (indirect, via electron transport chain) oxygen inhibition of the denitrification conversions and NO inhibition on the cytochrome c oxidase. The processes that were modeled are: (1) oxygen reduction, (2) nitrate reductase synthesis, (3) nitrate reduction, (4) nitrite reductase synthesis, (5) nitrite reduction, (6) NO reductase synthesis, (7) NO reduction.