Table 2.
Results of select genome-wide association studies of late-onset Alzheimer disease
| Genome-wide association studies | Study design | Population | Major genes identified |
|---|---|---|---|
| Reiman et al. 2007 | Case–control | US | APOE, GAB2 |
| Bertram 2008 | Family-based | US | APOE, ATXN1, CD33, GWA_14q31 |
| Lambert et al. 2009 | Case–control | US, Europe | APOE, CLU, CR1 |
| Harold et al. 2009 | Case–control | US, Europe | APOE, CLU, PICALM |
| Seshadri et al. 2010 | Case–control | US, Europe | APOE, BIN1 |
| Naj et al. 2011 | Case–control | US, Europe | MS4A6A/MS4A4E, EPHA1, CD33, CD2AP |
| Hollingworth et al. 2011 | Case–control | US, Europe | ABCA7, MS4A6A/MS4A4E, EPHA1, CD33, CD2AP |