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. Author manuscript; available in PMC: 2013 Oct 3.
Published in final edited form as: Cell Metab. 2012 Oct 3;16(4):487–499. doi: 10.1016/j.cmet.2012.09.004

Figure 1.

Figure 1

Partial restoration of plasma lipid levels by IRE1α silencing in XBP1 deficient mice. (A) Plasma TG and (B) cholesterol levels of male mice with the indicated genotypes measured at fed state. (C) Expression of lipid metabolism genes in male Xbp1LKO mice determined by qRT-PCR. n = 8–9 per group. (D) Xbp1LKO mice were i.v. injected with siRNAs targeting luciferase or IRE1α mRNA. Plasma TG and (E) cholesterol levels were measured at indicated time points. n = 8–9 per group. (F) Xbp1LKO mice were sacrificed 2 or 8 days after siRNA or PBS injection. Hepatic mRNA levels were measured by qRT-PCR. Values represent mean ± SEM. n = 2 (PBS), or 3–6 (siRNA). *P <0.05, **P <0.01, ***P <0.001.