Table 6.

Estimates of the dynamic treatment regime marginal structural model and corresponding 95% bootstrap confidence intervals allowing for a squared threshold term, comparing the always atypical (AA) regime with the perphenazine and atypical (PA) regime. The outcome model additionally adjusted for baseline covariates (estimates provided in the Appendix). The parameter PA(θ = 30) corresponds to the expected 12-month outcome for the always treat with perphenazine regime, thus, is equal to β̂₂ + β̂₃30 from Eq. (4).

	12-month PANSS score			12-month QOL score
Covariates	MI est.	Avg Boot est.	95% Boot CI	MI est	Avg Boot est.	95% Boot CI
AA	62.9	62.9	(50.9, 74.7)	4.3	4.2	(3.5, 5.2)
PA(θ = 30)	60.8	61.3	(58.2, 73.0)	4.2	4.2	(3.3, 5.2)
Threshold, θ	7.7×10−1	6.7×10−1	(3.3×10−1, 1.02)	−2.5×10−2	−1.4×10−2	(−4.0, 1.0)×10−2
Threshold2, θ2	−6.0×10−3	−5.2×10−3	(−8.6, −2.0)×10−3	−2.0×10−4	1.0×10−4	(−1.4, 3.0)×10−4