Table 3.

Progression to AD-type dementia and rate of cognitive decline with respect to biomarker status at baseline^a

Abbreviations: AD = Alzheimer disease; CI = confidence interval; HR = hazard ratio; MMSE = Mini-Mental State Examination; p-tau = tau phosphorylated at threonine 181; t-tau = total tau.

^aDementia-free survival and the HR were calculated using Cox regression analyses with correction for age, gender, and educational level. Baseline MMSE scores and slope values of annual change in MMSE score were estimated using mixed models with correction for age, gender, educational level, and center. Values are estimated assuming that subjects are 50% female, are 70 years of age, and have 11 years of education.

^bAbnormal CSF t-tau was defined as a value ≥375 pg/mL; hippocampal atrophy was defined as a volume of both left and right hippocampus of <5.39 cm³.

^cDifferences in baseline MMSE between the groups were not statistically significant.

^dThe p value compared with both markers normal = 0.1.

^eThe p value compared with both markers normal = 0.02.