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. 2012 Oct 18;8(10):e1002941. doi: 10.1371/journal.pgen.1002941

Figure 6. Polycomb group (PcG) multiprotein PRC1-like complex component Chromobox homolog 7 (CBX7) associates with the L1-RNP and inhibits retrotransposition.

Figure 6

(A) Lanes 1–3: CBX7 binds weakly with the L1 RNP in an RNA-dependent manner. Lanes 4–9: Co-immunoprecipitation of V5-tagged CBX7 by pc-L1-1FH is greatly enhanced by coexpression of tagged MOV10 proteins. (B) When overexpressed in the cell culture assay, both CBX7 and PRC1 component CBX8 significantly inhibit L1 retrotransposition, without obvious cell toxicity (C).