Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Oct 18;8(10):e1002703. doi: 10.1371/journal.pcbi.1002703

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 Ryser et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

A Starting from the initial conditions described in Figure 3, the RANKL and OPG concentrations, the osteoclast population density (OC) and the tumor density (Tumor) are shown after 30, 60 and 90 days, respectively. The growing tumor produces OPG at rates (green) and (blue), with a control case (red). Length of domain is , and only the right halves of the symmetric fields are shown. Scales are as in Figure 4, and OPG is in pmol/mm. B Left: zoom in on RANKL at 90 days in panel A. Right: the RANKL gradients are obtained by taking the spatial derivatives of the respective fields. C The simulation described in panel A is repeated for different initial RANKL levels , and different levels of OPG production by cancer cells . After 90 days, the following quantities are shown: distance traveled by osteoclasts (Distance), total number of active osteoclasts (OC), and total tumor mass (Tumor).

Inline graphic — A Starting from the initial conditions described in Figure 3, the RANKL and OPG concentrations, the osteoclast population density (OC) and the tumor density (Tumor) are shown after 30, 60 and 90 days, respectively. The growing tumor produces OPG at rates (green) and (blue), with a control case (red). Length of domain is , and only the right halves of the symmetric fields are shown. Scales are as in Figure 4, and OPG is in pmol/mm. B Left: zoom in on RANKL at 90 days in panel A. Right: the RANKL gradients are obtained by taking the spatial derivatives of the respective fields. C The simulation described in panel A is repeated for different initial RANKL levels , and different levels of OPG production by cancer cells . After 90 days, the following quantities are shown: distance traveled by osteoclasts (Distance), total number of active osteoclasts (OC), and total tumor mass (Tumor).