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. 2012 Oct 18;8(10):e1002703. doi: 10.1371/journal.pcbi.1002703

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© 2012 Ryser et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A Starting from the initial conditions described in Figure 3, the PTHrP and RANKL concentrations, the osteoclast population density (OC) and the tumor density (Tumor) are shown at 45 and 90 days, respectively. The initial host–tissue level of RANKL is . For , tumor produces PTHrP at rates . Length of domain is , only the right halves of the symmetric fields are shown, the units of the y-axes are as in Figure 4, and PTHrP has units . B The simulations in A were repeated for the initial host tissue level of RANKL .

Inline graphic — A Starting from the initial conditions described in Figure 3, the PTHrP and RANKL concentrations, the osteoclast population density (OC) and the tumor density (Tumor) are shown at 45 and 90 days, respectively. The initial host–tissue level of RANKL is . For , tumor produces PTHrP at rates . Length of domain is , only the right halves of the symmetric fields are shown, the units of the y-axes are as in Figure 4, and PTHrP has units . B The simulations in A were repeated for the initial host tissue level of RANKL .