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. 2012 Oct 18;8(10):e1002703. doi: 10.1371/journal.pcbi.1002703

Figure 8. PTHrP and OPG production by tumor.

Figure 8

A Starting from the initial conditions described in Figure 3, the PTHrP, RANKL and OPG concentrations, the osteoclast population density (OC) and the tumor density (Tumor) are shown at 30, 60 and 90 days, respectively. The initial RANKL level is Inline graphic. The growing tumor produces PTHrP at a fixed rate Inline graphic, and three different levels of tumor-derived OPG production Inline graphic are considered. Length of the domain is 15 mm, only the right halves of the symmetric fields are shown. Units of the y-axes are as in Figure 7, and the OPG field has units of Inline graphic. B The simulation described in panel A is performed for varying values of Inline graphic and Inline graphic, and the total tumor mass at 90 days is presented.