Table 4. Associations between MAP4K4 SNPs and TNF-α/IL-6 (subgroup).
| Genotype | N | TNF-α (ng/L) | IL-6 (ng/L) | |
| rs11674694 | CC | 238 | 3.65±11.03 | 0.91±1.78 |
| CT | 224 | 2.74±4.68 | 1.02±1.57 | |
| TT | 37 | 2.47±3.22 | 1.27±1.89 | |
| padd | – | – | 0.91 | 0.0127 |
| rs13003883 | TT | 199 | 3.06±6.24 | 1.09±1.74 |
| TA | 242 | 2.48±4.51 | 0.95±1.80 | |
| AA | 61 | 6.07±18.70 | 0.84±0.94 | |
| padd | – | – | 0.34 | 0.0094 |
| rs2236936 | CC | 244 | 2.81±5.77 | 1.04±1.61 |
| CG | 212 | 3.23±10.28 | 0.99±1.93 | |
| GG | 44 | 4.67±9.26 | 0.68±0.49 | |
| padd | – | – | 0.08 | 0.0252 |
Data represent means ±SD. Prior to statistical analysis, cytokine levels were adjusted for gender, age, and BMI. padd – p-value additive inheritance model; nominal associations marked by bold fonts. SNP – single nucleotide polymorphism.