Table 1.

Fine-mapping and haplotype analysis of the C10ORF67/10p12 locus in 486 sarcoidosis cases and 943 controls in the Black Women’s Health Study.

C10ORF67/10p12		Risk allele
			Allele frequency (%)		OR2 (95%CI)	P for trend	P permutated3
			Cases (n)	Controls (n)
rs1398024 (index SNP)1		A	45.5 (485)	47.3 (941)	0.92 (0.78–1.07)	0.28	-
rs11013452 (best SNP in BWHS)		A	15.5 (486)	18.6 (942)	0.80 (0.65–0.99)	0.04	-
Haplotype Analysis
rs1398024	rs11013452	Haplotype frequency (%)
C	G	45.0		43.0	1.00 (reference)
C	A	9.8		10.0	1.13 (0.81–1.57)	0.89	0.99
A	G	40.0		39.0	1.04 (0.87–1.25)	0.61	0.92
A	A	5.7		8.6	0.52 (0.35–0.77)	0.006	0.01

¹OR=0.81 (95%CI: 0.69–0.96) Franke et al., Gastroenterology 2008.

²Adjusted for % of African ancestry, age, and region of residence.

³Permutation 10,000 times.