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The influence of sampling times (in hours) on shrinkage of CL and Vc when observations per subject are two (a), four (b), or eight (c). S2-1: (0.25, 24), S2-2: (0.5, 20), S2-3: (2, 16), and S2-4: (4, 12); S4-1: (0.25, 1, 16, 24), S4-2: (0.5, 2, 12, 20), S4-3: (1, 4, 8, 12), and S4-4: (2, 4, 6, 8); and S8-1: (0.25, 0.5, 1, 2, 12, 16, 20, 24), S8-2: (0.5, 1, 2, 4, 10, 12, 16, 20), S8-3: (1, 2, 4, 6, 8, 10, 12, 16), and S8-4: (0.5, 2, 4, 6, 8, 12, 18, 24)
