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. 2012 Sep 20;14(4):927–936. doi: 10.1208/s12248-012-9407-9

Table I.

Descriptions of Simulations Conducted to Evaluate the Empirical Shrinkage Equations Using a Linear Random-Intercept Model

Simulation scenario Number of observations Interindividual variability Residual variability Shrinkage (%)a Level of shrinkageb
1 12 0.4 0.33 5.3 Low
2 12 0.3 1 48.1 Medium
3 12 0.01 4 97.1 High
4 6 0.4 0.33 10.2 Low
5 6 0.3 1 64.9 Medium
6 6 0.01 4 98.5 High

aCalculated based on the derived variance-based shrinkage equation (Eq. 7a) and the predefined values for the interindividual and residual variability used for simulations

bThe level of shrinkage is defined as follows: Low (≤15%); Medium (45–65%); and High (≥90%)