Table I.
Simulation scenario | Number of observations | Interindividual variability | Residual variability | Shrinkage (%)a | Level of shrinkageb |
---|---|---|---|---|---|
1 | 12 | 0.4 | 0.33 | 5.3 | Low |
2 | 12 | 0.3 | 1 | 48.1 | Medium |
3 | 12 | 0.01 | 4 | 97.1 | High |
4 | 6 | 0.4 | 0.33 | 10.2 | Low |
5 | 6 | 0.3 | 1 | 64.9 | Medium |
6 | 6 | 0.01 | 4 | 98.5 | High |
aCalculated based on the derived variance-based shrinkage equation (Eq. 7a) and the predefined values for the interindividual and residual variability used for simulations
bThe level of shrinkage is defined as follows: Low (≤15%); Medium (45–65%); and High (≥90%)