Table II.

PK Parameters Used for Simulation 2

PK parameters	Population mean	Interindividual variability
CL (L/h)	30	10% or 40%a
Vc (L)	70	10% or 40%a
Vp (L)	200	10% or 40%a
Q (L/h)	20	10% or 40%a
KA	1.5	10% or 40%a
Residual error	10–80% (CV%)b

CL clearance, Vc central volume of distribution, Vp peripheral volume of distribution, Q inter-compartmental clearance, KA absorption rate constant, CV coefficient of variation

^aEither 10% or 40% was used for each simulation

^bEither 10%, 20%, 40%, or 80% was used depending on the purpose of the simulation