Table II.
PK parameters | Population mean | Interindividual variability |
---|---|---|
CL (L/h) | 30 | 10% or 40%a |
Vc (L) | 70 | 10% or 40%a |
Vp (L) | 200 | 10% or 40%a |
Q (L/h) | 20 | 10% or 40%a |
KA | 1.5 | 10% or 40%a |
Residual error | 10–80% (CV%)b |
CL clearance, Vc central volume of distribution, Vp peripheral volume of distribution, Q inter-compartmental clearance, KA absorption rate constant, CV coefficient of variation
aEither 10% or 40% was used for each simulation
bEither 10%, 20%, 40%, or 80% was used depending on the purpose of the simulation