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Ligand-accessible regions of SERT. Regions available to ligands in the S1 (yellow) and S2 (cyan) pockets are displayed as surfaces. Selected residues that define each pocket are displayed as sticks (atomtype color). For clarity, only the main TM contributors to SERT ligand binding pockets are highlighted: TM 1 (pink), TM 3 (green), TM 6 (gold), TM 8 (brown) and EL 4 (blue)
