Table III.

Comparison of Exposure of a Nanosuspension and an Imwitor/Tween Formulation for Compound C in Beagle Dogs

Dose	Formulation	AUC	T max
30 mg/kg	0.5 mL/kg Imwitor/Tween	194 ± 60	2.2 ± 1.8
100 mg/kg	0.5 mL/kg Imwitor/Tween	162 ± 60	2.0 ± 1.7
30 mg/kg	5 mL/kg nanosuspension	15.4 ± 3.2	0.75 ± 0.43
100 mg/kg	5 mL/kg nanosuspension	27.6 ± 35.7	0.83 ± 0.29

The nanosuspension resulted in significantly lower exposures compared to the Imwitor/Tween suspension despite providing comparable exposures in an earlier screening study in rats

AUC area under the plasma concentration curve