Table III.
Dose | Formulation | AUC | T max |
---|---|---|---|
30 mg/kg | 0.5 mL/kg Imwitor/Tween | 194 ± 60 | 2.2 ± 1.8 |
100 mg/kg | 0.5 mL/kg Imwitor/Tween | 162 ± 60 | 2.0 ± 1.7 |
30 mg/kg | 5 mL/kg nanosuspension | 15.4 ± 3.2 | 0.75 ± 0.43 |
100 mg/kg | 5 mL/kg nanosuspension | 27.6 ± 35.7 | 0.83 ± 0.29 |
The nanosuspension resulted in significantly lower exposures compared to the Imwitor/Tween suspension despite providing comparable exposures in an earlier screening study in rats
AUC area under the plasma concentration curve