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Mitigation of Positive Food Effect via the use of Nanosuspension Formulations in Commercial Products
| Product | Food effect (% increase AUC) for nanosuspension | Food effect (% increase AUC) for original/early formulations |
|---|---|---|
| EMEND® | 20% (125 mg), 9% (80 mg)a | 2.7-fold (100 mg) |
| TRICOR® | 5% (145 mg)a | 35% (160 mg) |
| MEGACE® ES | 36% (625 mg) | 2-fold (800 mg) |
| TRIGLIDETM | 14% (160 mg)a | 35% (160 mg) |
AUC area under the plasma concentration curve
aExposures within bioequivalence bounds
