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In vivo catabolites and metabolites. The tissue, tumor, or liver, in which the metabolite or catabolite if formed is indicated below each structure. The relative potency of the compounds formed in tumor tissue and/or liver is noted. The free thiol compounds, DM1 and DM4, are not shown since >in vitro IC50 values for these compounds are highly variable due to their rapid oxidation to form mixed disulfides in cell culture medium
