Table 1.

Tumor suppressor miRNAs differentially expressed in colorectal cancer compared to normal mucosa and their predicted targets.

miRNA	Expression status in CRC (↑,↓)	Predicted target gene	Reference
TUMOR SUPPRESSOR miRNAs
let-7 family	↓	KRAS	Akao et al. (2006a), Torrisani et al. (2007), Han et al. (2012), Wang et al. (2011a), Earle et al. (2010), Slattery et al. (2011)
miR-9	↓		Lujambio et al. (2008), Bandres et al. (2009)
miR-16	↓		Earle et al. (2010)
miR-26b	↓		Earle et al. (2010)
miR-34b/c	↓	C-MYC, E2F2, CDK6	Lujambio et al. (2008), Kalimutho et al. (2011), Toyota et al. (2008)
miR-129-2	↓		Bandres et al. (2009)
miR-137	↓	CDC42	Bandres et al. (2009)
miR-143	↓	KRAS, DNMT3A, ERK5	Michael et al. (2003), Akao et al. (2006b), Slaby et al. (2007), Wang et al. (2009), Motoyama et al. (2009), Chen et al. (2009), Earle et al. (2010), Ng et al. (2009)
miR-145	↓	IRS-1, c-myc, SOX52	Michael et al. (2003), Akao et al. (2006b), Slaby et al. (2007), Wang et al. (2009), Motoyama et al. (2009), Chen et al. (2009), Earle et al. (2010)
miR-148a	↓	TGIF2	Lujambio et al. (2008), Kalimutho et al. (2011)
miR-191	↓		Earle et al. (2010)
miR-192	↓		Earle et al. (2010), Balaguer et al. (2011)
miR-196a	↓		Earle et al. (2010)
mir-200c	↓	ZEB1, ZEB2	Chen et al. (2012a), Burk et al. (2008), Chen et al. (2012b)
miR-215	↓		Earle et al. (2010), Slattery et al. (2011)
miR-342	↓	DNMT1	Grady et al. (2008), Wang et al. (2011b)
miR-941	↓	ADAM15	Yan et al. (2011)
miR-1247	↓		Yan et al. (2011)