Table 2.
Sub-network enrichment analysis for TB-regulated proteins in relation to cell processes, regulation of disease, expression targets, and protein-binding partners
| Relationship | Name | No. of measured neighbors | Median change | P-value |
|---|---|---|---|---|
| Proteins/chemicals-regulating cell processes | B lymphocyte differentiation | 7 | −1.61 | 0.007 |
| Xenobiotic clearance | 17 | 1.12 | 0.012 | |
| LDL oxidation | 5 | 1.34 | 0.015 | |
| Smooth muscle cell proliferation | 8 | 1.33 | 0.019 | |
| Lipid metabolism | 9 | 1.33 | 0.022 | |
| Mitochondrial damage | 14 | 1.13 | 0.029 | |
| Blood vessel permeability | 6 | 1.35 | 0.038 | |
| DNA degradation | 14 | 1.34 | 0.041 | |
| Proteins/chemicals-regulating diseases | Hypersensitivity | 5 | 1.34 | 0.018 |
| Emphysema | 5 | 1.13 | 0.022 | |
| Genotoxicity | 5 | −1.67 | 0.024 | |
| Body weight | 5 | −1.67 | 0.029 | |
| Expression targets | RAC-alpha serine/threonine–protein kinase | 6 | −1.62 | 0.024 |
| Thioredoxin | 5 | 1.35 | 0.036 | |
| Binding partner | Heat shock protein A8 | 5 | −1.39 | 0.041 |