. Author manuscript; available in PMC: 2012 Oct 19.

Published in final edited form as: Dev Comp Immunol. 2009 Mar 21;33(8):901–912. doi: 10.1016/j.dci.2009.02.008

Table 4.

Summary of potential 1,25D3-regulated genes that are homologous to the identified dolphin genes and/or their isoforms (listed in Tables 1 and 2).

Dolphin gene	Microarray study in human SCC25 cells^a		Genome-wide screens (consensus and nonconsensus VDREs)^a		Other studies
Dolphin gene	Gene	Up/downregulated	Human genes	Mouse genes	Gene	Up/downregulated
CALM3	CALML3	Up	CALM1,2,3		CALM2 human breast cancer cells^c	Up
CYC1	CCND2	Down	Cyclins A,B,D,E,G,H,K,M,T	Cyclins A,B,D,H	CCNK human prostate cancer cells^b	Up
	CCNG2	Up			CYC1, CCNG1, CCNG2 human breast cancer cells^c	Up
					CCNG1, CCNG2 human keratinocytes^g	Up
					CCND1 mouse osteoblasts^d	Down
					CCND1 human breast cancer cells^f	Down
CDC10	CDC25	Down	CDC2,6,7,10,23,25,26,27	CDC2,7,25,26,27,45L	CDC6 mouse osteoblasts^d	Down
	CDC2L6	Up			CDC2 human prostate cancer cells^e	Down
					CDC2 human keratinocytes^g	Up
BUB3	NA		Bub1,3	Bub3	BUB3 human keratinocytes^g	Down
HINT1	NA		HINT1,2	HINT2
MAPK6	MAPK13	Up	MAPK1,3,6,7,9,10,11,12,14	MAPK6	MAPK5 human breast cancer cells^c	Down
AKAP10	AKAP12	Up	AKAP1,3,7,8L,10,13		AKAP12 human cancer and normal prostate cells^e	Up
					AKAP8 human keratinocytes^g	Up
Ptpn12	PTPN1	Up	PTPN2,3,4,7,14,18,22	PTPN2,7,14
	PTPNS1	Up
HSBP1	NA		HSBP1
ARNT1	HIF1α	Up	ARNT2, ARNTL	HIF1α, HIF3α
BRCA1	NA		BRCA2		BRCA2 human breast cancer cells^c	Down
MED11	NA		MED8	MED8
APAF1	NA		APAF1
CRADD	NA		CRADD

Results are primarily derived from the work of Wang et al., as listed in the first four columns. Gene targets identified through other investigations are presented in the final columns. See text for further explanation.

[71].

[101].

[100].

[103].

[102].

[104].

[99].