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. 2012 Aug 16;287(43):36041–36050. doi: 10.1074/jbc.M112.370403

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — The shift to vesicles for the Ser-340/341 mutant is also induced by negative charge and is selective. A, phospho-mimetic mutant Flag-ATP7B^{R875,S340/341D} is localized to vesicles in basal (upper panel) and copper-depleted (100 μm BCS for 2 h) conditions (lower panel). B, Flag-ATP7B^R875,S478A, Flag-ATP7B^R875,S481A, and Flag-ATP7B^R875,S1453A behave as wt Flag-ATP7B^R875. They are located in the ER in basal conditions, and traffic to vesicles upon treatment with 100 μm CuCl₂ for 2 h (Scale bar: 5 μm).