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Partial suppression of GMQ action on ASIC3 by palm mutations. Currents were measured by whole-cell voltage clamp to −60 mV from CHO cells transfected with the mutant ASIC3 channels. SSIN curves and activation curves are shown for the mutants ASIC3-E79A (A) and ASIC3-E423A (B) in the absence (open symbols) or presence of 1 mm GMQ (filled symbols). Fit parameters are shown in supplemental Table S1 (n = 4–5). Error bars represent S.E.
