Fig. 1.

Sequence similarity network of the GST superfamily generated by Pythoscape and visualized in Cytoscape. To compact the view for this figure, networks were layed out using the organic layout in Cytoscape rather than the distances computed from a similarity metric. In all, 664 representative nodes are used to describe pairwise relationships among 7447 sequences. (A) Representative network with functional classes colored, if annotated by SwissProt in a family (The UniProt Consortium, 2011). Family membership is indicated if one or more sequences in the abstracted node are associated with that family. (B) Full non-abstracted network for the group of GSTs found mostly in eukaryotes (boxed in A)