Table 3.
Comparison of pharmacokinetic parameters of common NSAIDS in llamas
| |
IV dosages (mean values) |
PO dosages (mean values) |
||||||
|---|---|---|---|---|---|---|---|---|
|
Parameter (Units) |
Meloxicam (present study) |
Phenylbutazone[8] |
Ketoprofen[7]* |
Flunixin meglumine[6] |
Meloxicam (present study) |
Phenylbutazone[8] |
||
| S | R | Sum | ||||||
|
AUC (hr*μg/mL) |
43.96 |
80.1 |
168.9 |
176.4 |
345.3 |
49.0 |
68.35 |
60.8 |
|
Cl (mL/min/kg) |
0.190 |
1.11 |
0.22 |
0.21 |
0.43 |
0.78 |
N/A |
N/A |
|
T
MAX
(hr) |
N/A |
N/A |
N/A |
N/A |
21.4 |
4.37 |
||
|
T ½ λz(hr) |
17.4 |
2.03 |
5.49 |
5.41 |
5.45 |
1.47 |
22.7 |
7.09 |
|
Vss(L/kg) |
0.235 |
0.155 |
0.100 |
0.095 |
0.195 |
0.030 |
N/A |
N/A |
|
Dose (mg/kg) |
0.50 |
5.0 |
2.2 |
2.2 |
4.4 |
2.2 |
1.0 |
5 |
| F (%) | N/A | N/A | N/A | N/A | 76.0 | 69.9 | ||
* For the ketoprofen study, a racemic mixture of S and R enantomers were administered to each animal. PK values from each enantomer as well as the sum (or in the case of half –life, average) of both are reported here.
AUC = area under the curve extrapolated to infinity; Cl = plasma clearance; TMAX; = time to CMAX; T ½ λz = terminal half-life; Vss = volume of distribution at steady state; F = fraction of the dose absorbed.