Table 4.
Comparison of pharmacokinetic parameters of meloxicam in domestic animal species, PO administration
| |
PO administration (mean values) |
||||
|---|---|---|---|---|---|
|
Parameter |
Llamas* |
Cattle* |
Goats* |
Horses
**
|
Sheep* |
| (Units) | (present study) | [18] | [19] | [20] | [21] |
|
AUC
INF
(hr*μg/mL) |
68.35 |
164.46 |
23.24 |
NR |
75.09 |
|
Cl/F (mL/min/kg) |
0.248 |
0.1 |
NR |
NR |
0.220 |
|
C
MAX
(μg/mL) |
1.31 |
3.10 |
0.736 |
1.73 |
1.715 |
|
T
MAX
(hr) |
21.4 |
11.64 |
15 |
3.4 |
19.0 |
|
T ½ λz (hr) |
22.7 |
27.54 |
11.8 |
NR |
15.4 |
|
Vz/F (L/kg) |
0.487 |
0.242 |
NR |
NR |
0.293 |
|
Dose (mg/kg) |
1.0 |
1.0 |
0.5 |
0.6 |
0.99 |
| F (%) | 76.0 | 100.0 | 79.0 | 95.6 | 72.0 |
NR = not reported.
* Non-compartmental pharmacokinetic analysis.
** Compartmental pharmacokinetic analysis.
AUCINF = area under the curve extrapolated to infinity; Cl/F = Cl per fraction of the dose absorbed; CMAX = maximum plasma concentration; TMAX; = time to CMAX; T ½ λz, T ½β = terminal half-life; Vz/F = Vz per fraction of the dose absorbed; F = fraction of the dose absorbed.