Table 5.
Comparison of pharmacokinetic parameters of meloxicam in domestic animal species, IV administration
| |
IV administration (mean values) |
|||||
|---|---|---|---|---|---|---|
|
Parameter |
Llamas* |
Cattle* |
Goats* |
Horses
**
|
Sheep* |
Camels* |
| (Units) | (present study) | [18] | [19] | [20] | [21] | [22] |
|
AUC
INF
(hr*μg/mL) |
43.96 |
82.34 |
29.74 |
NR |
49.26 |
346.7 |
|
Cl or Cl
T
(mL/min/kg) |
0.190 |
0.1 |
0.298 |
0.34 |
0.169 |
0.032 |
|
C0(μg/mL) |
6.16 |
5.93 |
3.12 |
NR |
4.96 |
NR |
|
T ½ λz or T ½
β
(hr) |
17.4 |
20.35 |
10.9 |
8.54 |
14.0 |
40.2 |
|
Vss (L/kg) |
0.235 |
0.171 |
0.245 |
0.12 |
178.7 |
0.093 |
| Dose (mg/kg) | 0.5 | 0.5 | 0.5 | 0.6 | 0.5 | 0.6 |
NR = not reported.
* Non-compartmental pharmacokinetic analysis.
** Compartmental pharmacokinetic analysis.
AUCINF = area under the curve extrapolated to infinity; Cl = plasma clearance; ClT = total body clearance; C0 = Concentration extrapolated to time 0 using log-linear regression of the first two time points; T ½ λz, T ½ β = terminal half-life; Vss = volume of distribution at steady state.