Table 1.
Mean cocaine choice ED50 value in mg/kg per injection (95% confidence limits; CL) under baseline (saline) conditions and during 7-day treatment with m-fluoroamphetamine, (+)-phenmetrazine, (+)-methamphetamine, napthylisopropylamine and (±)-fenfluramine, or during removal of cocaine or food availability.
| Treatment Condition | ED50 (95% CL) |
|---|---|
| Baseline (n=8) | 0.017 (0.016 – 0.017) |
| m-Fluoroamphetamine 0.032 mg/kg/h (n=4) | 0.024 (0.019 – 0.030)* |
| m-Fluoroamphetamine 0.1 mg/kg/h (n=4) | 0.032 (0.013 – 0.075) |
| m-Fluoroamphetamine 0.32 mg/kg/h (n=4) | 0.117 (0.057 – 0.237)A |
| Phenmetrazine 0.032 mg/kg/h (n=4) | 0.030 (0.016 – 0.056) |
| Phenmetrazine 0.1 mg/kg/h (n=4) | 0.024 (0.012 – 0.049) |
| Phenmetrazine 0.32 mg/kg/h (n=4) | 0.055 (0.053 – 0.058)B |
| Methamphetamine 0.032 mg/kg/h (n=4) | 0.013 (0.009 – 0.019) |
| Methamphetamine 0.056 mg/kg/h (n=4) | 0.024 (0.010 – 0.056) |
| Methamphetamine 0.1 mg/kg/h (n=4) | 0.021 (0.003 – 0.132)C |
| Napthylisopropylamine 0.1 mg/kg/h (n=4) | 0.013 (0.010 – 0.016) |
| Napthylisopropylamine 0.32 mg/kg/h (n=4) | 0.018 (0.012 – 0.029) |
| Napthylisopropylamine 1.0 mg/kg/h (n=3) | 0.0 11 (0.006 – 0.021)D |
| Fenfluramine 0.1 mg/kg/h (n=4) | 0.014 (0.01 – 0.034) |
| Fenfluramine 0.32 mg/kg/h (n=4) | 0.014 (0.006 – 0.034)B |
| No Cocaine (n=4) | 0.074 (0.048 – 0.115)*,E |
| No Food (n=4) | 0.003 (0.002 – 0.004)* |
Significantly different from baseline as defined by non-overlapping 95% confidence limits.
Mean ED50 value was estimated in one monkey because cocaine choice did not exceed 50% at any cocaine dose and treatment eliminated all responding in another monkey.
Mean ED50 value could not be determined because cocaine choice was 100% for some components and eliminated responding during other components of the choice session in one monkey.
Mean ED50 value was estimated because cocaine choice did not exceed 50% in one monkey and was not lower than 50% in another monkey at any cocaine dose.
Mean ED50 value could not be determined because treatment eliminated responding in one monkey.
ED50 value based on doses associated with prevailing discriminative stimuli.