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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: J Pain. 2012 Mar 15;13(4):317–327. doi: 10.1016/j.jpain.2011.12.003

Figure 6. Effects of weekly ARM390 in the assay of acid-depressed ICSS.

Figure 6

Unlike SNC80, ARM390 only exacerbated acid-induced depression of ICSS. (a) Abscissa: frequency of electrical brain stimulation in Hz (log scale). Ordinate: Percent maximum control rate (%MCR). For this group of 6 rats, the mean±SEM MCR was 64.4±2.5. Two-way ANOVA revealed main effects of frequency [F(9,45)=73.7, p<0.001] and treatment [F(4,20)=26.1, p<0.001] and a significant interaction [F(36,180)=6.4, p<0.001], and filled symbols indicate a significant difference from Veh-LA (Holm-Sidak post hoc test, p<0.05). (b) Abscissa: Treatment conditions. Ordinate: Percent baseline number of stimulations per component. For this group of 6 rats, the mean±SEM baseline number of stimulations per component was 292.8±28.8. One-way ANOVA indicated a significant effect of treatment [F(5,25)=4.2, p<0.0001). The dollar sign ($) indicates significantly different from Veh-Veh, and asterisks indicate a significant difference from Veh-LA (Newman-Keuls, p<0.05). All points and bars show mean±SEM.