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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: J Pain. 2012 Mar 15;13(4):317–327. doi: 10.1016/j.jpain.2011.12.003

Figure 7. Effects of twice-weekly ARM390 on control and acid-depressed ICSS.

Figure 7

ARM390 was administered twice each week, once before lactic acid vehicle and once before 1.8% lactic acid, with at least 3 days between ARM390 doses. Abscissa: Dose ARM390 in mg/kg. Ordinate: Percent baseline number of stimulations per component, and for this group of four rats, the mean±SEM baseline number of stimulations per component was 276.5±33.9. Two-way ANOVA indicated a significant main effect of acid treatment [F(1,3)=18.6, p=0.023], but no significant effect of ARM390 [F(3,9)=1.7, p=0.23] and no significant interaction [F(3,9)=0.4, p=0.76]. All bars show mean±SEM.