Figure 4. D1Rs boost corticoaccumbal release when glutamate receptors are blocked.

A, FM1-43 destaining curves showed that blockade of glutamate receptors with NBQX, APV and MCPG alone did not alter FM1-43 destaining but they blocked inhibition and further potentiated release when combined with SKF38393. B, average destaining half-times treatments shown in panel A. C, inhibition by the D2R agonist quinpirole was prevented by the glutamate antagonists NBQX, APV and CPCCOEt. The glutamate antagonists NBQX, APV and MCPG did not alter destaining after quinpirole. D, distribution of mean t_1/2 of release for destaining curves shown in panel C.