Table 2.
Decay time constants (ms) of IPSCs of NL neurons under different drug and stimulus conditions
| LF | MF/HF | |||||
|---|---|---|---|---|---|---|
| Drug and stimulus | Control (n) | Drug | P value | Control (n) | Drug | P value |
| Sr2+ | ||||||
| Single-pulse | 10.6 ± 1.1 (5) | 32.6 ± 5.8 | <0.05 | 50.6 ± 6.3 (6) | 103.5 ± 5.6 | <0.05 |
| 100 Hz train | 64.9 ± 5.7 (6) | 140.8 ± 16.2 | <0.01 | 342.4 ± 36.2 (6) | 363.1 ± 31.9 | >0.05 |
| EGTA-AM | ||||||
| Single-pulse | 7.4 ± 1.0 (5) | 7.5 ± 0.9 | >0.05 | 63.1 ± 20.2 (7) | 34.3 ± 8.5 | <0.05 |
| 100 Hz train | 67.4 ± 14.2 (4) | 46.8 ± 7.5 | <0.05 | 305.0 ± 76.1 (4) | 120.8 ± 13.4 | <0.05 |
| NNC 771 | 69.3 ± 7.0 (4) | 70.0 ± 4.6 | >0.05 | 250.5 ± 44.1 (5) | 290.1± 40.2 | <0.05 |
| TPMPA | 44.0 ± 7.8 (4) | 34.3 ± 7.0 | <0.05 | 334.6 ± 59.8 (9) | 233.0 ± 40.1 | <0.001 |
| SR95531 | n.d. | n.d. | 324.7 ± 42.9 (6) | 311.2 ± 50.7 | >0.05 | |
| Low Ca2+ | 80.7 ± 11.1 (6) | 46.2 ± 9.7 | <0.05 | 264.6 ± 27.9 (7) | 174.0 ± 24.5 | <0.001 |
n: number of cells; n.d.: not determined. Weighted time constants (mean ± SEM), and P values of paired t test are reported.