Table 4.
Mean z-scores for weight, length, and head circumference (HC) at age one year, by exposure to combination ARV regimen with TDF vs. combination ARV regimen without TDF during pregnancy, unadjusted and adjusted for other covariates.
| Gestation or Age-adjusted Z-score | Among combination ARV-exposed infants N, Mean (SD) | Exposed to combination regimens with TDF | Exposed to combination regimens without TDF | TDF vs non-TDF P-value2 | ||
|---|---|---|---|---|---|---|
|
| ||||||
| Unadjusted N, Mean (SD) | Adjusted1 Mean (SE) | Unadjusted N, Mean (SD) | Adjusted1 Mean (SE) | |||
| Weight | 585, −0.07 (1.16) | 217, −0.11 (1.20) | −0.09 (0.08) | 368, −0.05 (1.14) | −0.04 (0.06) | 0.62 |
| Length | 582, −0.05 (1.09) | 215, −0.17 (1.00) | −0.17 (0.07) | 367, 0.02 (1.14) | −0.03 (0.06) | 0.04 |
| HC | 570, 0.34 (1.20) | 209, 0.23 (1.10) | 0.17 (0.08) | 361, 0.41 (1.25) | 0.42 (0.06) | 0.02 |
TDF=tenofovir disoproxil fumarate, HC=head circumference, SD=standard deviation, SE=standard error
The estimates presented above are from separate models for each outcome adjusted for covariates with p<0.10 in multivariate models, including: Weight z-score at 1 year: gestational age and high maternal viral load prior to delivery; Length z-score at 1 year: Latino ethnicity, high maternal viral load prior to delivery, and maternal use of tobacco during pregnancy; HC z-score at 1 year: low income level, low caregiver education level, and maternal use of illicit drugs during pregnancy.
P-value from linear regression model comparing adjusted means for TDF-exposed vs unexposed.