Table 3. Summary of the linkage signals detected in the combined sample and in samples 1 and 2 separately by our latent class modeling.
| MOD scorea | LOD scoreb | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Sample | Sample | ||||||||
| Region | Marker (Mb) | Dimension | Model | 1 and 2 | 1 | 2 | Subtype | Diagnosis | Description |
| Enhancement of previously detected signals | |||||||||
| 13q14 | D13S291 (44.82) | Mania | D-AO | 5.20 | 1.68 | 3.64 | Subtype 2 (Figure 1a) | Across all diagnoses | Presence of manic symptoms |
| New signals | |||||||||
| 2q34 | D2S322 (210.80) | Delusion | R-AO | 3.40 | 1.58 | 2.05 | Subtype 2 (Figure 1b) | Mostly BP (but not exclusively) | Questionable levels of delref, delgran and delrel. Mild level of delper. |
| 15q25 | D15S211 (81.19) | Bizarre behavior | D-AU | 3.81 | 1.81 | 2.03 | Subtype 2 (Figure 1e) | Across all diagnoses | Mild or moderate levels of bizarre behavior, especially bizaggr and bizglob. |
| 7p14 | D7S671 (41.96) | Anhedonia | D-AO | 3.48 | 3.88 | 0.62 | Subtype 3 (Figure 1i) | Across all diagnoses | Marked level of anhedonia, across all items. |
| 9q33 | D9S299 (108.69) | Delusion | R-AO | 3.48 | 1.26 | 2.28 | Subtype 3 (Figure 1a) | Mostly SZ (but not exclusively) | Mild or moderate levels of delper, delref, delgran and delrel. |
The map used for the genomic locations was the Ensembl map (http://uswest.ensembl.org/Homo_sapiens/Info/Index).
The MOD score was obtained in the combined sample by maximizing the LOD score over the mode of inheritance (D, dominant vs R, recessive) and the type of analysis (AO, affected-only vs AU, affected/unaffected).
A LOD score was obtained in samples 1 and 2 by fixing the mode of inheritance and the type of analysis to the one previously obtained in the combined sample. The sum of the LOD scores of samples 1 and 2 may not exactly add up to the MOD score obtained in the combined samples (1 and 2) because of the possibility that the LOD scores were maximized for different values of the recombination fraction. MOD scores or LOD scores showing suggestive or significant linkage are indicated in bold.