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. Author manuscript; available in PMC: 2013 Feb 9.
Published in final edited form as: J Med Chem. 2011 Dec 2;55(3):977–994. doi: 10.1021/jm200568c

Figure 2.

Figure 2

Representative CXCR4 interactions with several different classes of CXCR4 ligands, including SDF-1α (natural agonist), vMIP-II (natural antagonist), HIV-1 gp120 (viral ligand), AMD3100 (small synthetic organic molecule), and DV1/9 (modified peptides). Orange arrows represent disease and drug related pathways, and blue arrows indicate physiologic functions of CXCR4.