Tumor growth inhibition after intravenous injection of free DOX, L-DOX, or Lac-L-DOX in tumor-bearing mice at a DOX dose of 5 mg/kg body weight.
Notes: Data are shown as the mean ± standard deviation (n = 10). ***P < 0.05, statistically significant compared with phosphate-buffered saline control; **P < 0.05, statistically significant compared with free DOX; *P < 0.05, statistically significant compared with L-DOX.
Abbreviations: DOX, doxorubicin; L-DOX, liposomal doxorubicin; Lac-L-DOX, lactosylated liposomes encapsulating doxorubicin; PBS, phosphate-buffered solution.