Table 3.

Survival of mice after treatment with free DOX, L-DOX, and Lac-L-DOX in HepG2 tumor-bearing mice^a

Treatment	Tumor inhibition ratiob (%)	MSTc (days)	ILSd (%)	Log-rank P value
PBS	0	28	0	–
Free DOX	38.7	34	21.4	0.0612
L-DOX	60.8	42	50	0.00178
Lac-L-DOX	80.9	70	150	0.000557 (0.0205)e

Notes:

^an = 10 for each treatment group;

^btumor inhibition ratio was calculated by (C − T)/C × 100%;

^cMST represents the mean survival time;

^dILS (%) was calculated by (MST of the treated mice/MST of control mice − 1) × 100%;

^eP value was calculated in comparison with L-DOX.

Abbreviations: MRT, mean residence time; DOX, doxorubicin; L-DOX, liposomal doxorubicin; Lac-L-DOX, lactosylated liposomes encapsulating doxorubicin; MST, mean survival time; ILS, increased life span; PBS, phosphate-buffered saline.