Table 1.
APS Treatment Before Initial MRI Scan and Interval Preceding Each Follow-up Scan
| Initial Scan (N=211) | 1st Follow-up (n=211) | 2nd Follow-up (n=139) | 3rd Follow-up (n=82) | 4th Follow-up (n=31) | |
|---|---|---|---|---|---|
| Interscan interval, mean (SD), Ya | NA | 3.07 (1.57) | 3.31 (0.92) | 3.89 (1.21) | 3.00 (0.36) |
| No treatment, No. (%) | 31(14.7) | 8 (3.8) | 8 (5.8) | 6 (7.3) | 2 (6.5) |
| Clozapine treatment, No. (%) | 15(7.1) | 37 (17.5) | 34 (24.5) | 23(28.0) | 10 (32.3) |
| APS dose, mean (SD), CPZ mg equivalents/d | 245.3 (350.9) | 348.9 (323.3) | 438.9 (333.6) | 519.9(320.5) | 579.9 (336.3) |
| Type of APS treatment, mean (SD) % of total CPZ dose-yearsb | |||||
| Typical APSs | 58.2 (45.6) | 31.9 (39.3) | 19.3(30.4) | 16.4(30.0) | 16.5 (31.7) |
| Nonclozapine atypical APSs | 38.8(46.1) | 57.4 (41.7) | 62.2(40.6) | 60.9 (43.2) | 60.7 (44.9) |
| Clozapine | 3.0(13.7) | 10.7(26.9) | 18.5(36.0) | 22.7(39.3) | 22.8 (39.0) |
Abbreviations: APS, antipsychotic; CPZ, chlorpromazine; MRI, magnetic resonance imaging; NA, not applicable.
a
First follow-up is the time interval between the initial and first follow-up images; second follow-up, the time interval between the first and second follow-up images; etc.
b
One CPZ dose-year=100 mg of CPZ per day for 1 year.