Table 1.
Frequencies of KIR framework genesa
| KIR3DL3* | Frequency % (n) | KIR3DL2* | Frequency % (n) | KIR2DL4* | Frequency % (n) |
|---|---|---|---|---|---|
| 00101 | 2.5 (5) | 00101d | 10 (20) | 00102d | 8 (8) |
| 00103 | 0.5 (1) | 00103d | 17 (34) | 00103d | 64 (64) |
| 00104 b | 1 (2) | 00201d | 7 (14) | 00202 | 1 (1) |
| 00201 | 1 (2) | 00301 | 3.5 (7) | 00501 | 21 (21) |
| 00202 | 1 (2) | 00302 | 3 (6) | 00602 | 3 (3) |
| 00205 | 2 (4) | 00501 | 1 (2) | 0080101/03d | 23 (23) |
| 00206 | 2.5 (5) | 00502b | 0.5 (1) | 0080102 | 1 (1) |
| 00207 | 2 (4) | 006 | 5.5 (11) | 00802d | 17 (17) |
| 00208 | 1 (2) | 00701d | 5.5 (11) | 011 | 11 (11) |
| 00301d | 8.5 (17) | 008 | 3.5 (7) | 01201 | 5 (5) |
| 00402d | 5 (10) | 00901 | 1.5 (3) | 01202 b | 1 (1) |
| 005 | 8 (16) | 00902 | 2.5 (5) | 013 b | 1 (1) |
| 00601 | 1 (2) | 010 | 7 (14) | 017 b | 1 (1) |
| 007 | 1 (2) | 01301 | 13 (26) | 018b | 1 (1) |
| 00801 | 2.5 (5) | 01302b | 0.5 (1) | 019b | 1 (1) |
| 00901d | 13 (26) | 01303b | 0.5 (1) | 020b | 1 (1) |
| 00902 | 1 (2) | 016 | 0.5 (1) | 021 b | 1 (1) |
| 00905 b | 0.5 (1) | 019 | 2 (4) | 022 b | 5 (5) |
| 01001 | 3.5 (7) | 023 | 2 (4) | Negative f | 1 (1) |
| 01002 | 0.5 (1) | 025 c | 0.5 (1) | ||
| 01101 | 3 (6) | 028c | 1 (2) | ||
| 01102 | 1 (2) | 029c | 3 (6) | ||
| 012 | 1.5 (3) | 032c | 0.5 (1) | ||
| 01302 | 1.5 (3) | 033c | 0.5 (1) | ||
| 01402d | 4.5 (9) | 040c | 1.5 (3) | ||
| 01404 | 1 (2) | 041c | 1 (2) | ||
| 01406 | 6.5 (13) | 057b | 1 (2) | ||
| 01408b | 1 (2) | 058b | 0.5 (1) | ||
| 01502 | 1 (2) | 059b | 0.5 (1) | ||
| 017 | 0.5 (1) | 060b | 0.5 (1) | ||
| 01802b | 0.5 (1) | 061b | 0.5 (1) | ||
| 020 | 0.5 (1) | 062b | 0.5 (1) | ||
| 02101 | 0.5 (1) | 3dl1/3dl2 fusion genese | 2.5 (5) | ||
| 022 | 0.5 (1) | ||||
| 02501 | 0.5 (1) | ||||
| 02502 | 1 (2) | ||||
| 02701 | 1 (2) | ||||
| 028 | 0.5 (1) | ||||
| 032 | 2.5 (5) | ||||
| 034 | 0.5 (1) | ||||
| 035 | 4.5 (9) | ||||
| 036 | 0.5 (1) | ||||
| 041b | 0.5 (1) | ||||
| 049b | 2 (4) | ||||
| 050b | 1 (2) | ||||
| 051b | 0.5 (1) | ||||
| 052b | 1 (2) | ||||
| 053b | 1.5 (3) | ||||
| 054b | 0.5 (1) | ||||
| 055b | 0.5 (1) |
Allele frequencies are calculated for KIR3DL3 and KIR3DL2. It was assumed that each individual carried two copies of these genes. Because not all haplotypes carry KIR2DL4, the carrier frequency is reported for this locus.
Novel allele described in this study and designated as such by the WHO Committee for Factors of the HLA System.
Alleles with sequences not reported in IPD-KIR database 2.3.0. Our sequence submissions were assigned as confirmatory by the WHO Committee for Factors of the HLA System.
Intron variation not distinguished
Five individuals carry a chimeric gene resulting from the fusion of KIR3DL1 and KIR3DL2 (Jiang et al. 2010;Norman et al. 2009). These alleles include KIR3DL1*059 (three individuals), KIR3DL1*064 (one individual), and KIR3DL1*065 (one individual).
One individual does not carry KIR2DL4 alleles.