Table 3.

Multivariable Survival Analysis Results by median methylation level (< median is the reference group)

Gene	Outcome	HR (95% CI)	p-value*
RIL	TTFR	1.53 (0.85, 2.77)	0.16
	OS	1.12 (0.76, 1.67)	0.57
HIN-1	TTFR	1.49 (0.83, 2.68)	0.19
	OS	1.21 (0.82, 1.80)	0.34
RASSF1A	TTFR	1.93 (1.02, 3.67)	0.045
	OS	1.74 (1.11, 2.74)	0.016
CDH13	TTFR	0.75 (0.42, 1.33)	0.32
	OS	1.15 (0.77, 1.70)	0.50

The models include age (continuous), tumor size (continuous), S-phase, ER (continuous) and PR (continuous).

*P-value from Cox regression model.