Table 1.
RNA sample list
| Mouse suture tissues | ||||||
|---|---|---|---|---|---|---|
|
Time point |
Genotype |
Suture type |
|
|||
| E16.5 * |
Wildtype |
Coronal, Posterior-frontal, Lambdoid, Parietal bone |
|
|||
| D0 # |
Wildtype |
Coronal, Lambdoid |
|
|||
| D0 |
Fgfr2cC342Y/+ |
Posterior frontal, Sagittal |
|
|||
| D1 |
Fgfr2cC342Y/+ |
Coronal, Lambdoid |
|
|||
| D5 |
Wildtype |
Lambdoid, Parietal bone |
|
|||
| D5 |
Fgfr2cC342Y/+ |
Posterior frontal, Sagittal |
|
|||
| D10 |
Wildtype |
Coronal, Lambdoid |
|
|||
| D10 |
Fgfr2cC342Y/+ |
Posterior-frontal, Sagittal |
|
|||
|
Human suture cells |
|
|||||
|
Patient code |
Phenotype |
Sex |
Age (months) |
Suture type |
Passage |
|
| AC 125 |
Sagittal synostosis |
M |
7 |
Unfused Coronal |
P5, P10 |
|
| AC 124 |
Metopic synostosis |
M |
7 |
Unfused Coronal |
P4, P8 |
|
| AC 126 |
Metopic synostosis |
F |
9 |
Unfused Coronal |
P4 |
|
| AC 141 |
Sagittal synostosis |
M |
6 |
Unfused Coronal |
P3 |
|
| AC 125 |
Sagittal synostosis |
M |
7 |
Unfused Lambdoid |
P4 |
|
| AC 120 |
Crouzonoid syndrome |
F |
96 |
Fused Sagittal |
P9 |
|
| AC 113 |
Multi-suture synostosis |
F |
10 |
Fused Coronal |
P5 |
|
| AC 34 |
Multi-suture synostosis |
F |
5 |
Fusing Sagittal |
P5 |
|
|
Kusa 4b10 - Osteogenesis assay+ |
|
|||||
|
Induced cells |
Uninduced cells |
|
||||
| - |
0 |
|
||||
| 3 |
3 |
|
||||
| 7 |
7 |
|
||||
| 14 |
14 |
|
||||
| 21 | 21 | |||||
*E refers to embryonic day.
#D refers to postnatal day.
+days after induction or days after the equivalent time point for uninduced cells.