Table 1.
Correlation between AZGP1 expression and clinical and pathological characters in HCC
|
Variable |
AZGP1 protein |
||||
|---|---|---|---|---|---|
| All cases | Low expression | High expression | χ 2 | P valueα | |
| Age(years) b |
|
|
|
0.134 |
0.714 |
| 48 |
119 |
46 (38.7) |
73 (61.3) |
|
|
| ≥ 48 |
127 |
52 (40.9) |
75 (59.1) |
|
|
| Mean ± SD(47.9 ± 11.8) |
|
|
|
|
|
| Gender |
|
|
|
0.099 |
0.753 |
| Female |
27 |
10 (37.0) |
17(63.0) |
|
|
| Male |
219 |
88(40.2) |
131(59.8) |
|
|
| HBsAg |
|
|
|
0.673 |
0.412 |
| Yes |
213 |
87 (40.8) |
126 (59.2) |
|
|
| No |
33 |
11(33.3) |
22 (66.7) |
|
|
| AFP (ng/ml) |
|
|
|
6.182 |
0.013 |
| ≤ 20 |
104 |
32 (30.8) |
72 (69.2) |
|
|
| > 20 |
142 |
66 (46.5) |
76 (53.5) |
|
|
| Liver cirrhosis |
|
|
|
9.244 |
0.002 |
| Yes |
177 |
81 (45.8) |
96 (54.2) |
|
|
| No |
69 |
17 (24.6) |
52 (75.4) |
|
|
| Tumor size (cm) |
|
|
|
0.457 |
0.499 |
| ≤ 5 |
127 |
48 (37.8) |
79 (62.2) |
|
|
| > 5 |
119 |
50 (42.0) |
69 (58.0) |
|
|
| Tumor multiplicity |
|
|
|
0.042 |
0.837 |
| Single |
130 |
51 (39.2) |
79 (60.8) |
|
|
| Multiple |
116 |
47 (40.5) |
69 (59.5) |
|
|
| Tumor differentiation |
|
|
|
9.347 |
0.025 |
| Well (I) |
33 |
6 (18.2) |
27 (81.8) |
|
|
| Moderate (II) |
125 |
54 (43.2) |
71 (56.8) |
|
|
| Poor (III) |
76 |
35 (46.1) |
41 (53.9) |
|
|
| Undifferentiation (IV) |
12 |
3 (25) |
9 (75) |
|
|
| Clinical Stage |
|
|
|
2.154 |
0.541 |
| I |
16 |
5 (31.3) |
11 (68.7) |
|
|
| II |
93 |
33 (35.5) |
60 (61.5) |
|
|
| III |
106 |
46 (43.4) |
60 (56.6) |
|
|
| IV |
31 |
14 (45.2) |
17 (54.8) |
|
|
| Vascular invasion |
|
|
|
1.966 |
0.161 |
| Yes |
73 |
34 (46.6) |
39 (53.4) |
|
|
| No | 173 | 64 (37.0) | 109 (63.0) | ||
αChi-square test; b patients were divided according to the median age; AFP, alpha-fetoprotein; HBsAg, hepatitis B surface antigen; AZGP1, zinc-alpha2-glycoprotein.